Work Packages

Overview
Predictors of rheumatic disease in healthy individuals
Genes and environment as risk factors for development of rheumatic disease
Predictors of clinical outcome in patients with arthritis
Synovial tissue markers for prediction of outcome and of response to therapy
Cartilage and bone markers for prediction of outcome and response to therapy
Application to other rheumatic diseases : Myositis
Predictors of response to new therapies
Identification of new targets for therapy using experimental rodent models for arthritis
Validation of targets and development of new therapy in murine arthritis models
Validation of targets: in humanised in vivo and human in vitro models
Technologies - genetic analysis
Technologies - cell sorting, gene expression and cytometric profilin
Technologies - proteomics and antibody profiling
Technologies - molecular bioinformatics and biostatistics
Technologies - cell biology for evaluation of targeted therapy
Data management systems
Bioethics and legal issues
Commercialisation aspects
Dissemination
Economic evaluation of treatment
Technology training and knowledge transfer
Management

Overview

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