Université d'Evry, Paris

Located at the Genopole of Evry and at Hôpital Lariboisière - AP-HP in Paris.

GenHotel-EA 3886 is dedicated to the search for rheumatoid arthritis (RA) genes. With ECRAF  (European Consortium on Rheumatoid Arthritis
Families) that it coordinates, created in 1995 with European Union funding from the BIOMED 2 program, GenHotel-EA 3886 benefits from a
resource of more than 5.000 DNA and clinical data from RA patients and family members. ECRAF published in 1998 the first genome scan for RA
(1), refined in 2004  with 1088 highly polymorphic markers (2).

GenHotel-EA 3886 has developed its own bioinformatics tools to investigate RA susceptibility candidate genes and participates to GUIDAEL, the EULAR bioinformatics project on RA genes coordinated by Pr Tom HUIZINGA in Leiden . In addition to its main  project of testing 200 RA susceptibility candidate genes, GenHotel-EA 3886 tests the proposed new RA candidate genes published by other groups, comforting
PTPN22 (3) or rejecting  other genes (4) those as new important RA genes.

GenHotel-EA 3886 also contributes to the modelisation of the first RA gene, HLA-DRB1 (5) GenHotel-EA 3886 shares its scientific potential in:i) releasing on the internet its genotyping data (see www.genhotel.com ) ii) opening its lab to external teams for testing more candidates genes iii) offering the testing of those genes for other purposes, such as investigation for RA severity (6) or treatment responses.

This sharing activity, especially the housing of members of external teams, with 30 stays at GenHotel-EA 3886 organized in the last 4 years,
results in a significant training activity for the European Union.

Ref. :
(1)Cornélis F, Fauré S, Martinez M, Prud'homme J, Fritz P, Dib C, Alves H, Tran, TH, Delaye A, Prince N, Lefevre C, Thomas G, Poirier M, Soubigou S Alibert O, Lasbleiz S, Fouix S, Lioté F, Loste MN, Lepage V, Charron D, Gyapay G, Lopes-Vaz A, Kuntz D, Bardin T, and Weissenbach J for ECRAF. New susceptibility locus for rheumatoid arthritis suggested by a genome wide linkage study. Proc Natl Acad Sci USA 1998;95:10746-10750

(2) Osorio J, Bukulmez H, Petit-Teixeira E, Michou L, Pierlot C, Cailleau, Moindrault S, Lemaire I, Lasbleiz S, Alibert O, Quillet P, Bardin T,  Prum B, Olson J and Cornélis F for ECRAF.  Dense genome-wide linkage analysis of rheumatoid arthritis including covariates. Arthritis Rheum 2004;50:2757-65.

(3) J Wipff , Y Allanore , A Kahan, O Meyer, L Mouthon, L Guillevin, C Pierlot, E Glickmans, T Bardin, C Boileau, F Cornélis and P Dieudé.
Lack of association between the protein tyrosine phosphatase non receptor  22 (PTPN22) - 620W Allele and systemic sclerosis in the French Caucasian population. Ann Rheum Dis, published online 7 Feb 2006.

(4) Tommasi C, Petit-Teixeira E, Cournu-Rebeix I, Caponi L, Pierlot C, Fontaine B, Cornélis F, Migliorini P., PADI4 gene in multiple
sclerosis : A family-based association study. J Neuroimmun. 2006 May, sous presse

(5) Michou L, Croiseau P, Petit-Teixeira E, du Montcel ST, Lemaire I, Pierlot C, Osorio J, Frigui W, Lasbleiz S, Quillet P, Bardin T, Prum B,
Clerget-Darpoux F, Cornelis F; the European Consortium on Rheumatoid Arthritis Families. Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis. Arthritis Res Ther. 2006 Apr 28;8(3):R79

(6) Van Der Helm-van Mil AHM, Dieude P, Schonkeren JJM, Cornélis F and Huizinga TWJ. No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of the phenotype. Rheumatology
2004;53:314-7 

GenHotel- EA 3886 France invites applications for a post-doctoral position, see web site:

http://www.GenHotel.com

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