Autocure

Read more in the latest issue of AutoCurious

 

Click here to read the full newsletter

 

The human genome and rheumatic diseases

“With a biomarker you are a beggar, with a
cohort you are a king”…....In genetics we
today have in one sense too much data
and at the same time we need much more
data. One of the major challenges is linking
these massive new genetic data sets
with clinical phenotype and outcome. Read more

 

Gums & Joints – a joint AutoCure venture

Gums & Joints, a newly funded FP7 EU collaborative project, with an aim to investigate protein citrullination as a link between periodontal disease and rheumatoid
arthritis, recently had its kick-off meeting in Krakow, Poland. The new consortium, where AutoCure scientists from Karolinska Institutet, Birmingham and The Kennedy Institute of Rheumatology are represented, will focus on different aspects of the link between the two inflammatory
conditions, using a multidisciplinary approach. Read more

 

”I was convinced that the wrist pain had to do with computer work”

Harrie van der Velde, 49, is by nature a very optimistic person but when he was diagnosed with an aggressive type of RA about five months ago he became depressed.
– If I had known anything about the first symptoms of RA I would have come here to see a specialist much earlier, says
Harrie who is participating in IMPROVED, one of the clinical studies at Leiden University Medical Center. Read more

Click the image to download information leaflet

 

 

 

 

 

 

 

 

 

AutoCure is an EU funded research project within the FP6. Involved in the project are 26 different partners, of which 6 are industrial partners and 20 are from the acadeamia, from all over Europe. » read more

 

 

In the jubilieé issue of the newsletter AutoCurious (below), you can see selected articles from all 11 newsletters that have been published.

 

 

 

 

Information brochure

 

SELECTED PUBLICATIONS

Need for a wider view of autonomy in epidemiological research
Mats G Hansson, professor of biomedical ethics Centre for Research Ethics and Bioethics, Uppsala University, Department of Public Health and Caring Sciences, mats.hansson@crb.uu.se

http://www.bmj.com/cgi/content/full/bmj.c2335

 

Raychaudhuri S, Thomson BP, Remmers EF, Eyre S et al . Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet. 2009 Nov 8. [Epub ahead of print] PubMed PMID: 19898481. Abstract

 

Mahdi H, Fisher BA, Källberg H, Plant D et al. Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. Nat Genet. 2009 Nov 8. [Epub ahead of print] PubMed PMID: 19898480. Abstract

 

January 23-25 AutoCure had its final meeting after 5 successfull years. Summary of the meeting, here.

 

 

AutoCure booth at Eular 2010, Rome

Parts of the project management,

Susanne Karlfeldt and Lars Klareskog.

COURSE

 

THE SCIENTIFIC BASIS OF RHEUMATOLOGY: A PRIMER FOR CLINICIANS

Athens, September 10-12, 2010

 

This special course will provide an overview of the current status of basic and clinical research in rheumatology, focusing particularly on developments in the past decade, during which there has been an explosion of new information in this field. Part of the lectures will focus on biologic processes underlying rheumatic diseases while the others will analyze developments in specific rheumatic diseases. This course will provide both researchers and clinicians with a comprehensive understanding of current knowledge on the scientific basis of rheumatology. For more information and preliminary program, please click here.

 

Members of the AutoCure consortium
have, for the first time, shown a link
between genes, smoking and specific
autoimmunity in the development of RA


In November 2009 researchers from The Kennedy Institute of Rheumatology in London and Karolinska Institutet in Stockholm published the article ”Specific interaction between genotype, smoking and autoimmunity to citrullinated a-enolase in the etiology of rheumatoid arthritis” in Nature Genetics. This is one of the most significant proofs so far of the strong gene-environment interaction that underlies the development of RA.

Nat Genet. 2009 Dec;41(12):1319-24

The article is a good proof of the excellent and successful collaboration"
(Karin Lundberg, PhD, Karolinska Institutet, Stockholm)
.....
"One of the most important publications within the AutoCure project so far"
(Professor Lars Alfredsson, Karolinska Institutet, Stockholm)

 

 


"Both screening and prevention is much needed"
( Professor Patrick Venables, The Kennedy Institute of Rheumatology, London)

 

"The importance of AutoCure in research is large"
(Peter Charles, Clinical Immunologist, The Kennedy Institute of Rheumatology, London)
....

"Free radicals seem to have a positive impact on the immune defense system"(Peter Olofsson, CEO Redoxis)

 

For more interesting quotes and articles, please read the latest issue of the newsletter AutoCurious here


 

 

 

 

 

 

 

 

Gaining more knowledge on early diagnosis and early treatment of RA

AutoCure has now passed its three year anniversary, and many programs are in their most active phase, and will remain so during the coming two years. Looking both on what has been accomplished and even more on what can be achieved in the remaining time, AutoCure coordinator Lars Klareskog wants to highlight a few accomplishments as well as a few urgent needs: Read more

 

Unique chance to study the early mechanisms of RA

Catch RA-patients very early,
treat them aggressively and
do thorough regular follow
ups with ultrasound. That’s the
treatment recipe currently being
developed by the Rheumatology
Research Group (RRG)
at Birmingham University. Read more

Professor Chris Buckley

 

Early treatment standard in Vienna

Early treatment is not a new concept at the Vienna General Hospital (AKV) in Austria. AutoCure partner professor Josef Smolen
was among the first rheumatologists in Europe to open an early arthritis clinic 15 years ago. Many studies on outcome of RA
have provided his research group with convincing evidence that early and aggressive treatment is successful – more than 25 percent of the patients treated here are in full remission. Read more.

Professor Josef Smolen

 

 

 

 

 

 

 

 

Possible new treatment concept for early RA

Associate professor of biochemistry Günter Steiner is the only group leader in professor Josef Smolens research team who is a 100 percent basic science researcher. Read more

Professor Guenter Steiner

 

Regular exercise can reduce inflammation

New studies now confirm that moderate regular exercise is very beneficial for Myositispatients – and most likely also
for other inflammatory diseases. In the near future exercise could be made a common prescription ”drug”. Read more.

Professor Ingrid Lundberg

 

 

 

 

 

SEMINARS /COURSES

 

 

   
 
 
SHORT CUTS
 

 

 

Gender and Leadership in AutoCure

 

The AutoCure consortium
continues to focus on the
gender issue with the goal
to promote female
academic leadership in
rheumatology. Next step
in the action plan
(click here for full action plan)
is to start a survey where
all AutoCure members –
both women and men -
will be asked about attitudes,
obstacles etc. This will be
a scientific study and the
results may be published.
Another workshop on the
gender theme will be held
in 2 years.


***************************
The EULAR executive committee
will be asked to dedicate a full
session to leadership and
gender issues at the next congress.
To promote a gender balance
at future rheumatology congresses
and to facilitate the selection of
chairmen and speakers, AutoCure here publishes a list of the
female expertise within the
consortium: list of female speakers and chairmen. The list is also sent to EULAR.

 

 

 

 

 

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